The healthcare industry of the United States is facing a major issue – the opioid crisis. Opioid abuse is now a growing public health concern that is resulting in many opioid related deaths. Over the past decade, hospitals have also noted a prominent rise in the opioid-related visits. The epidemic is evident across multiple delivery points and the industry is still struggling to find an effective solution. The current scenario calls for quick implementation of the right strategies in association with improved health plans. Studies suggest that Pharmacy Benefit Managers (PBMs) and latest health plans are increasingly attempting to leverage data driven and evidence based approaches to change the behavioral patterns of patients. The healthcare industry is also counting on advancing technologies for support to control the opioid epidemic. Curbing opioid crisis needs a collaborated effort of all the sections of the healthcare industry including the government and various communities. However, healthcare leaders are also thinking of ways to address the issue in their respective organizations for immediate effect.